Those individuals who require dental work or any surgery may need to be pre-treated with an infusion of factor VIII to avoid hemorrhage. Hemophilia A affects between one in 5,000 to one in 10,000 males in most populations. { bidder: 'sovrn', params: { tagid: '346688' }}, { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_leftslot' }}, bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '1666926', position: 'btf' }}, These example sentences are selected automatically from various online news sources to reflect current usage of the word 'hemophilia.' { bidder: 'appnexus', params: { placementId: '11654156' }}, The presence of such a chemical may greatly hamper efforts to prevent or stop a major hemorrhage. (Males inherit one X and one Y chromosome, and therefore have only one X chromosome.). 'max': 8, { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_btmslot' }}, { bidder: 'appnexus', params: { placementId: '11654157' }}, { bidder: 'triplelift', params: { inventoryCode: 'Cambridge_SR' }}, pbjs.que = pbjs.que || []; This temporary plug, however, is too disorganized to serve as a long-term solution, so a series of chemical events occur, resulting in the formation of a more reliable plug. googletag.cmd = googletag.cmd || []; Hemophilia C is very rare, and much more mild than hemophilia A or B; it involves factor XI. }, tcData.listenerId); {code: 'ad_rightslot', pubstack: { adUnitName: 'cdo_rightslot', adUnitPath: '/2863368/rightslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, },{ {code: 'ad_topslot_a', pubstack: { adUnitName: 'cdo_topslot', adUnitPath: '/2863368/topslot' }, mediaTypes: { banner: { sizes: [[300, 50], [320, 50], [320, 100]] } }, }); { bidder: 'ix', params: { siteId: '195466', size: [728, 90] }}, {code: 'ad_btmslot_a', pubstack: { adUnitName: 'cdo_btmslot', adUnitPath: '/2863368/btmslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, { bidder: 'pubmatic', params: { publisherId: '158679', adSlot: 'cdo_leftslot' }}]}, This classification is based on the percentage of normal factor VIII activity present: Individuals with hemophilia B have symptoms very similar to those of hemophilia A, but the deficient factor is factor IX. { bidder: 'openx', params: { unit: '539971066', delDomain: 'idm-d.openx.net' }}, bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '776130', position: 'btf' }}, { bidder: 'appnexus', params: { placementId: '11654157' }}, { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_rightslot2' }}, Inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhages, spontaneous or traumatic, because of a defect in the blood-coagulating mechanism. { bidder: 'ix', params: { siteId: '555365', size: [300, 250] }}, iasLog("exclusion label : wprod"); { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_topslot_728x90' }}, }] storage: { googletag.cmd.push(function() { userIds: [{ { bidder: 'appnexus', params: { placementId: '11653860' }}, iasLog("criterion : cdo_l = en"); 'increment': 1, an anxiety disorder in which patients are driven to repeat the same act, such as washing their hands, over and over again, usually for many hours. bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '776156', position: 'atf' }}, ga('create', 'UA-31379-3',{cookieDomain:'dictionary.cambridge.org',siteSpeedSampleRate: 10}); The following concepts are important to understanding the inheritance of these diseases. About 30% of all people with hemophilia A or B are the first member of their family to ever have the disease. {code: 'ad_leftslot', pubstack: { adUnitName: 'cdo_leftslot', adUnitPath: '/2863368/leftslot' }, mediaTypes: { banner: { sizes: [[120, 600], [160, 600]] } }, { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_rightslot_flex' }}, { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_rightslot2_flex' }}, { bidder: 'pubmatic', params: { publisherId: '158679', adSlot: 'cdo_topslot' }}]}, { bidder: 'appnexus', params: { placementId: '11654208' }}, 'min': 8.50, { bidder: 'ix', params: { siteId: '195451', size: [300, 50] }}, { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_btmslot_300x250' }}, Hemophilia is a genetic disorder—usually inherited—of the mechanism of blood clotting. Because the clotting cascade uses amplification to rapidly plug up a bleeding area, absence or inactivity of just one clotting factor can greatly increase. Individuals with a family history of hemophilia may benefit from genetic counseling before deciding to have a baby. 'min': 3.05, { bidder: 'ix', params: { siteId: '555365', size: [120, 600] }}, { bidder: 'sovrn', params: { tagid: '705055' }}, { bidder: 'openx', params: { unit: '539971079', delDomain: 'idm-d.openx.net' }}, var googletag = googletag || {}; Add the power of Cambridge Dictionary to your website using our free search box widgets. These individuals have had the unfortunate occurrence of a spontaneous mutation; meaning that in their early development, some random genetic accident befell their X chromosome, resulting in the defect causing hemophilia A or B. { bidder: 'ix', params: { siteId: '194852', size: [300, 250] }}, }, The normal mechanism for blood clotting is a complex series of events involving the interaction of the injured blood vessel, blood cells (called platelets), and over 20 different proteins which also circulate in the blood. Can you spell these 10 commonly misspelled words? The most important thing that individuals with hemophilia can do to prevent complications of this disease is to avoid injury. anxiety caused by a dread of environmental perils, especially climate change.. the state of concern about the future of … { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_rightslot2' }}, pbjs.setConfig(pbjsCfg); Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors). bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '776160', position: 'atf' }}, {code: 'ad_rightslot2', pubstack: { adUnitName: 'cdo_rightslot2', adUnitPath: '/2863368/rightslot2' }, mediaTypes: { banner: { sizes: [[300, 250], [120, 600], [160, 600]] } }, {code: 'ad_topslot_a', pubstack: { adUnitName: 'cdo_topslot', adUnitPath: '/2863368/topslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, iasLog("criterion : cdo_pc = dictionary"); Bleeding can be particularly dangerous when it's entirely internal, with no visible wound, since the person may not be aware it's happening. googletag.pubads().setCategoryExclusion('lcp').setCategoryExclusion('resp').setCategoryExclusion('wprod'); The other 30% develop from a spontaneous genetic mutation. { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_rightslot' }}, Various types of factors VIII and IX are available to replace a patient's missing factors. "authorization": "https://dictionary.cambridge.org/auth/info?rid=READER_ID&url=CANONICAL_URL&ref=DOCUMENT_REFERRER&type=ENTRY_TRANSLATE&v1=english&v2=hemophilia&v3=&v4=english&_=RANDOM", (203) 746-6518 or (800) 999-6673. { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_topslot_728x90' }}, params: { There are three levels of factor VIII deficiency: severe, moderate, and mild. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. By race/ethnicity, the prevalence was 13.2 cases/100,000 among white, 11.0 among African-American, and 11.5 among Hispanic males. What made you want to look up hemophilia? pid: '94' { bidder: 'ix', params: { siteId: '555365', size: [160, 600] }},

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